cees dekker Things To Know Before You Buy
cees dekker Things To Know Before You Buy
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Rotary motion of DNA rotors on nanopores. Top row: Uncooked video of your Cy5 channel of every rotor. Middle row: corresponding solitary-particle localization outcomes of both of those ends of your DNA rotors. The placement of the present frame is marked as orange and blue dots, and the trajectory of the 10 frames before The present body is proven as good traces.
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The next content articles are merged in Scholar. Their mixed citations are counted just for the 1st report.
Deposition and atomic force microscopy of unique phthalocyanine polymers amongst nanofabricated electrodes
2010, formulated a new way (‘wedging transfer’) to manipulate nanostructures; very first report of DNA translocation by graphene nanopores; and understood hybrid nanopores by directed insertion of α-hemolysin into good-state nanopores
SMC complexes can go Bodily roadblocks bigger than their ring dimension, indicating a nontopological mechanism for DNA loop extrusion
Lots of related developments followed, in which our group proven diverse transistor variants for example solitary-electron transistors at place temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled many transistors into smaller evidence-of-theory Digital circuits.
Finding out DNA loop extrusion by SMC proteins for chromosome architecture with one-molecule assays.
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1). The current–voltage curves confirmed significant modulations with gate voltage, even at place temperature, which was in line with band bending in a very ~0.6 eV bandgap semiconducting nanotube. These facts also showed the conductance could be modulated by six orders of magnitude by switching the gate voltage. The outcome of the function — a place-temperature transistor made from an individual carbon nanotube molecule — were revealed in Mother nature in Might 1998.
[fourteen] In 2005 Dekker became involved with Netherlands-wide conversations about Clever Design and style, a motion that he has because Plainly distanced himself from. Dekker advocates that science and religion will not be in opposition but can be harmonized.
Cees Dekker is Distinguished College Professor at TU Delft. Experienced for a physicist, he pioneered nanotechnology with quite a few discoveries on carbon nanotubes during the nineteen nineties. Considering the fact that 2000, he moved to one-molecule biophysics and nanobiology. His latest exploration concentrates on (i) nanopores for protein sequencing; (ii) chromosome framework, particularly SMC motor protein; and (iii) building a living artificial mobile from lifeless molecules. Dekker is undoubtedly an elected member on the KNAW and fellow for the APS along with the IOP.
Such as, we consider the nucleopore intricate, a gateway in between the mobile nucleus plus the cytoplasm. This is an extremely challenging program and thus tricky to review within a cell, so we use biomimetics. We reconstruct holes and afterwards insert specific components of the nucleopore advanced to review transportation by way of it at the single-molecule stage.’
It absolutely was a really appealing time, during which I acquired loads of assistance from Delft University of Know-how, where I used to be a professor at enough time, And that i started a number of collaborations with molecular biologists. That aided me master a lot.’