Everything about ceesdekker
Everything about ceesdekker
Blog Article
In case you determine any important omissions or other inaccuracies during the publication listing, make sure you let's know.
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules
Dynamics of initiation, termination and reinitiation of DNA translocation via the motor protein EcoR124I
Non-equilibrium folding of specific DNA molecules recaptured approximately one thousand instances in the reliable condition nanopore
2010, designed a completely new way (‘wedging transfer’) to govern nanostructures; initial report of DNA translocation by means of graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into stable-point out nanopores
SMC complexes can go Actual physical roadblocks larger than their ring measurement, indicating a nontopological mechanism for DNA loop extrusion
We use nanofabricated microfluidic structures to pattern spatial boundaries for bacteria and biomimetic vesicles with reconstituted protein networks which evaluate the elemental purpose of spatial confinement within the molecular and mobile amount. Our initiatives include things like the subsequent:
Instance (one) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim with the pore is highlighted in red, and also a 3D rendering in the movement from the DNA rod is exhibited.
In 1993, to be a young and eager affiliate professor at Delft College of Technologies, I had to begin with focused the analysis initiatives of my team on measuring the electrical conductance of a single conducting-polymer molecule. Inside of two several years, we experienced created a device where only one wire of a phthalocyaninepolysiloxane polymer was connected among two carefully spaced metallic nanoelectrodes.
There was a person problem although — we did not observe any measurable electrical conduction from the single polymer molecules. We concluded that at the single-molecule degree, conducting polymers have been in fact not these kinds of good conductors, which was alternatively disappointing. We So broadened our view to test to uncover more promising molecules.
An built-in microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes
1999, initially measurement from the wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof for any new Luttinger description of interacting electrons in nanotubes
As an example, we look at the nucleopore elaborate, a gateway involving cees dekker the cell nucleus and also the cytoplasm. This is a really intricate technique and thus difficult to review within a cell, so we use biomimetics. We reconstruct holes and afterwards insert specific components of the nucleopore advanced to study transportation by means of it at the single-molecule stage.’
It had been a very intriguing time, all through which I received a great deal of aid from Delft University of Engineering, wherever I had been a professor at the time, and I commenced various collaborations with molecular biologists. That served me discover a good deal.’